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A p-value less than 0.05 was considered statistically significant, indicating a meaningful difference in treatment efficacy

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LTP or LTD could be induced in unitary connections between simultaneously recorded pairs of neurons with controlled absence of presynaptic spikes during intracellular tetanization (Figures 3A1A3, B1B3) and at excitatory synapses activated with extracellular electric stimulation (Figures 3C1C3, D1D3)